Reaction: PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR
PI3K/AKT signaling is initiated downstream of PDGFRA gain-of-function missense and in-frame deletion mutants as assessed by the presence of phosphorylated AKT in Western blot analysis (Heinrich et al, 2003; Osashi et al, 2005; Bahlawane et al, 2015; Paugh et al, 2013; reviewed in Corless et al, 2011).
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
ADP [cytosol]
ATP [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-9672177
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Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
ADP(3-)
Reactome.org link: R-HSA-9672177