Reaction: S1PR1 bind S1P
- in pathway: Lysosphingolipid and LPA receptors
The human gene EDG1 encodes S1PR1 which binds sphingosine 1-phosphate (S1P), a second messenger implicated in cell survival, cell migration, and inflammation (Hla & Maciag 1990). S1PR1 seems to couple with Gi proteins (Lee et al. 1996).
Reaction - small molecule participants:
S1P [extracellular region]
Reactome.org reaction link: R-HSA-9690449
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Reaction input - small molecules:
sphingosine 1-phosphate(1-)
Reaction output - small molecules:
Reactome.org link: R-HSA-9690449