Reaction: FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS
- in pathway: Signaling by FLT3 ITD and TKD mutants
SOS1-mediated nucleotide exchange on RAS downstream of activated FLT3 mutants leads to stimulation of the MAP kinase signaling cascade (Mizuki et al, 2000; Hayakawa et al, 2000; Masson et al, 2009; reviewed in Kazi and Ronnstrand, 2019).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9695853
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9695853