Reaction: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants
- in pathway: Signaling by FLT3 fusion proteins
SOS1-mediated nucleotide exchange on RAS is presumed to occur downstream of activated FLT3 fusion mutants, leading to increased phosphorylation of MAPK/ERK proteins (Grand et al, 2007; Vu et al, 2009; Troadec et al, 2017; Chonabayashi et al, 2013; reviewed in Kazi and Roonstrand et al, 2019).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9703441
======
Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9703441