Reaction: DHFR dimer reduces FOLA to DHF
- in pathway: Metabolism of folate and pterines
Cytosolic, dimeric dihydrofolate reductase (DHFR dimer) catalyzes the reduction of folate (FOLA) to dihydrofolate (DHF) (Chen et al. 1984). Crystal structures of DHFR bound to its substrate folate reveal it functions as a homodimer (Davies et al. 1990).
Reaction - small molecule participants:
NADP+ [cytosol]
DHF [cytosol]
FOLA [cytosol]
H+ [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-9709098
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Reaction input - small molecules:
folic acid
hydron
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
dihydrofolate(2-)
Reactome.org link: R-HSA-9709098