Reaction: GNAT3 exchanges GDP for GTP in TAS1R2:TAS1R3:sweet compound:GNAT3:GDP:GNB1,3:GNG13
Binding of a sweet tastant to the sweet taste receptor (TAS1R2:TAS1R3) causes a change in conformation that then causes the Galpha subunit (GNAT3, gustducin) of the associated heterotrimeric G protein complex to exchange GDP for GTP (Sainz et al. 2007). The TAS1R2 subunit is primarily responsible for activating guanylate nucleotide exchange by GNAT3 (Sainz et al. 2007).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-9728697
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-9728697