Reaction: TPMT transfers methyl group to 6TIMP, forming 6MeTIMP
- in pathway: Azathioprine ADME
Thiopurine methyltransferase (TPMT) can methylate thiopurine drugs and its metabolites (Weinshilboum et al. 1978). The methylation of 6-thioinosine 5’-monophosphate (6TIMP) leads to formation of 6-methylthioinosine monophosphate (6MeTIMP). Although an inactive metabolite in terms of inhibiting DNA and RNA synthesis, 6MeTIMP is still capable of inhibiting purine de novo synthesis (Bökkerink et al. 1993, Karim et al. 2013).
Reaction - small molecule participants:
H+ [cytosol]
AdoHcy [cytosol]
6MeTIMP [cytosol]
AdoMet [cytosol]
6TIMP [cytosol]
Reactome.org reaction link: R-HSA-9748979
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
6-Thioinosine-5'-monophosphate(2-)
Reaction output - small molecules:
hydron
S-adenosyl-L-homocysteine zwitterion
methylthioinosine monophosphate
Reactome.org link: R-HSA-9748979