Reaction: Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
- in pathway: MyD88 dependent cascade initiated on endosome
Second, Thr387 in the activation loop is phosphorylated, leading to full enzymatic activity.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-975134
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-975134