Meta-Biol : Pathways : MyD88 dependent cascade initiated on endosome

Pathway: MyD88 dependent cascade initiated on endosome

Reactions in pathway: MyD88 dependent cascade initiated on endosome :

IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9

MyD88 dependent cascade initiated on endosome

Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.

Innate Immune System

Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup

Immune System

Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system.