Reaction: IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
- in pathway: MyD88 dependent cascade initiated on endosome
IRAK4 is activated by autophosphorylation at 3 positions within the kinase activation loop, Thr-342, Thr-345 and Ser-346.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-975170
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-975170