Reaction: CYP3A4 monooxygenates ATVL to 2-OH-ATVL
- in pathway: Atorvastatin ADME
Atorvastatin lactone (ATVL) is hydroxylated to hydroxy-metabolites, predominantly by cytochrome P450 3A4 (CYP3A4) (Park et al. 2008). Statin lactones are metabolized to a much higher extent than their acid forms by CYP enzymes, suggesting that metabolism of the lactone is the relevant pathway for atorvastatin elimination (Jacobsen et al. 2000, Fujino et al. 2004, Filppula et al. 2021). Described here is the formation of 2-hydroxyatorvastatin lactone (2-OH-ATVL).
Reaction - small molecule participants:
2-OH-ATVL [cytosol]
H2O [cytosol]
NADP+ [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-9756138
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Reaction input - small molecules:
hydron
dioxygen
NADPH(4-)
Reaction output - small molecules:
2-hydroxyatorvastatin lactone
water
NADP(3-)
Reactome.org link: R-HSA-9756138