Reaction: CYP3A4 monooxygenates ATV to 4-OH-ATV
- in pathway: Atorvastatin ADME
Atorvastatin (ATV) is hydroxylated to hydroxy-metabolites, predominantly by cytochrome P450 3A4 (CYP3A4) (Fujino et al. 2004, Park et al. 2008). Here, ATV hydroxylation to 4-hydroxyatorvastatin (4-OH-ATV, aka para-hydroxyatorvastatin) is described.
Reaction - small molecule participants:
H2O [cytosol]
NADP+ [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-9756162
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Reaction input - small molecules:
hydron
dioxygen
NADPH(4-)
Reaction output - small molecules:
water
NADP(3-)
Reactome.org link: R-HSA-9756162