Reaction: RDH11 reduces RBP2:atRAL to RBP2:atROL
- in pathway: Retinoid metabolism and transport
Although the enzyme catalysing retinal reduction in human enterocytes is not identified, the best candidate is retinol dehydrogenase 11 (RDH11, RalR1). It is expressed in the intestine, has a basic pH optimum, and localises to the ER membrane where LRAT catalyses the next step in the pathway. However, RDH11 catalyses retinal reduction to retinol in vitro and uses NADPH as cofactor (Fierce et al. 2008).
Reaction - small molecule participants:
NADP+ [cytosol]
H+ [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-975629
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Reaction input - small molecules:
hydron
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
Reactome.org link: R-HSA-975629