Reaction: HSD11B1 hydrogenates PREDN to PREDL in hepatic cell
- in pathway: Prednisone ADME
Prednisone (PREDN) is hydrogenated to prednisolone (PREDL) by HSD11B1. The conversion of 11β-hydroxysteroids to 11-oxosteroids and vice versa is catalyzed by the enzymes 11β-hydroxysteroid dehydrogenase 1 and 2 (HSD11B1, HSD11B2). Although the activity of both enzymes is bidirectional in vitro, in vivo HSD11B1 acts as 11-oxosteroid reductase and HSD11B2 acts as 11β-hydroxysteroid dehydrogenase (Jamieson et al, 1995). HSD11B1 is ubiquitously expressed, with maximum activity in the liver, while HSD11B2 is mainly active in placenta, colon, and kidney cells (Ricketts et al, 1998).
Reaction - small molecule participants:
NADP+ [cytosol]
H+ [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-9757706
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Reaction input - small molecules:
hydron
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
Reactome.org link: R-HSA-9757706