Reaction: malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome
- in pathway: Beta-oxidation of very long chain fatty acids
Carboxylation of acetyl-CoA and decarboxylation of malonyl-CoA are two processes that can control the amount of the signal transducer malonyl-CoA in the cell. The decarboxylation is catalysed by MCD enzyme in the peroxisomal matrix (Sacksteder et al, 1999).
Reaction - small molecule participants:
Ac-CoA [peroxisomal matrix]
CO2 [peroxisomal matrix]
Malonyl-CoA [peroxisomal matrix]
Reactome.org reaction link: R-HSA-977317
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Reaction input - small molecules:
malonyl-CoA(5-)
Reaction output - small molecules:
acetyl-CoA(4-)
carbon dioxide
Reactome.org link: R-HSA-977317