Reaction: KDM5B demethylates histone H3 trimethyllysine-4 (H3K4me3)
KDM5B (PLU-1) demethylates histone H3 trimethyllysine-4 (H3K4me3, lysine-5 of the preprotein) in vitro and in embryonic cells (Christensen et al. 2007, Yamane et al. 2007, Kristensen et al. 2012) and is inferred to catalyze the same reaction in zygotes. KDM5A and KDM5B demethylate broad regions of H3K4me3 in cleavage stage embryos (inferred from mouse embryos).
Reaction - small molecule participants:
CH2O [nucleoplasm]
CO2 [nucleoplasm]
SUCCA [nucleoplasm]
2OG [nucleoplasm]
O2 [nucleoplasm]
Reactome.org reaction link: R-HSA-9822461
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Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
formaldehyde
carbon dioxide
succinate(2-)
Reactome.org link: R-HSA-9822461