Reaction: METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)
METTL23 catalyzes the asymmetric dimethylation of arginine-17 of histone H3.3 (arginine-18 of the preprotein) (inferred from mouse homologs). Dimethylation of histone H3.3 is required for assembly of H3.3 into chromatin in the male pronucleus of the zygote (inferred from mouse homologs).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
H+ [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-9822583
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
hydron
Reactome.org link: R-HSA-9822583