Reaction: KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)
KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3, lysine-28 of the preprotein) to yield histone H3 monomethyllysine-27 (H3K27me1) in embryonic cells (Agger et al. 2007, Hong et al. 2007, Lan et al. 2007) and is inferred to catalyze the same reaction in zygotes. KDM6A participates in demethylating genome-wide H3K27me3 in cleavage stage embryos (inferred from mouse homologs).
Reaction - small molecule participants:
CH2O [nucleoplasm]
CO2 [nucleoplasm]
SUCCA [nucleoplasm]
2OG [nucleoplasm]
O2 [nucleoplasm]
Reactome.org reaction link: R-HSA-9822985
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Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
formaldehyde
carbon dioxide
succinate(2-)
Reactome.org link: R-HSA-9822985