Reaction: Active PLCG1 hydrolyses PIP2
- in pathway: Role of phospholipids in phagocytosis
Inositol 1,4,5-triphosphate (IP3) is a second messenger produced by phospholipase C (PLC) metabolism of phosphoinositol 4,5-bisphosphate (PIP2) (Canossa et al. 2001).
Reaction - small molecule participants:
I(1,4,5)P3 [cytosol]
DAGs [plasma membrane]
H2O [cytosol]
PI(4,5)P2 [plasma membrane]
I(1,4,5)P3 [cytosol]
DAGs [plasma membrane]
H2O [cytosol]
PI(4,5)P2 [plasma membrane]
I(1,4,5)P3 [cytosol]
DAGs [plasma membrane]
H2O [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-167686
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
water
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
water
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1D-myo-inositol 1,4,5-trisphosphate(6-)
diglyceride
1D-myo-inositol 1,4,5-trisphosphate(6-)
diglyceride
1D-myo-inositol 1,4,5-trisphosphate(6-)
diglyceride
Reactome.org link: R-HSA-167686