Reaction: Squalene is oxidized to its epoxide
- in pathway: Cholesterol biosynthesis
Squalene monooxygenase (squalene epoxidase, SE) is located on the endoplamic reticulum. It catalyzes the oxidation of squalene to squalene 2,3-epoxide. SE seems to be an important rate-limiting enzyme in cholesterol biosynthesis.
Reaction - small molecule participants:
SQOX [cytosol]
H2O [cytosol]
NADP+ [cytosol]
H+ [cytosol]
O2 [cytosol]
SQNE [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-191299
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Reaction input - small molecules:
hydron
dioxygen
squalene
NADPH(4-)
Reaction output - small molecules:
(S)-2,3-epoxysqualene
water
NADP(3-)
Reactome.org link: R-HSA-191299