Reaction: HMGCR dimer reduces bHMG-CoA to MVA
- in pathway: Cholesterol biosynthesis
Dimeric 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR dimer) catalyzes the four-electron reduction of beta-hydroxy-beta-methylglutaryl-CoA (bHMG-CoA) to mevalonate (MVA). MVA concentrations in the cell are tightly controlled through the activity of HMGCR dimer, which is one of the most highly regulated enzymes in metabolism (Goldstein & Brown 1990).
Reaction - small molecule participants:
NADP+ [cytosol]
CoA-SH [cytosol]
MVA [cytosol]
bHMG-CoA [cytosol]
H+ [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-191352
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Reaction input - small molecules:
(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)
hydron
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
coenzyme A(4-)
(R)-mevalonate
Reactome.org link: R-HSA-191352