Reaction: Reduction of presqualene diphosphate to form squalene
- in pathway: Cholesterol biosynthesis
In the second step, FDFT catalyzes the reduction of presqualene diphosphate to squalene (Pandit et al. 2000).
Reaction - small molecule participants:
PPi [cytosol]
SQNE [cytosol]
NADP+ [cytosol]
H+ [cytosol]
NADPH [cytosol]
PSQPP [cytosol]
Reactome.org reaction link: R-HSA-191402
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Reaction input - small molecules:
hydron
NADPH(4-)
presqualene diphosphate
Reaction output - small molecules:
diphosphate(3-)
squalene
NADP(3-)
Reactome.org link: R-HSA-191402