Reaction: CYP7B1 7-hydroxylates 25OH-CHOL
- in pathway: Endogenous sterols
25-hydroxycholesterol (25OH-CHOL) is 7alpha-hydroxylated to cholest-5-ene-3beta,7alpha,25-triol (CHOL3b,7a,25TRIOL) by CYP7B1 (cytochrome P450 7B1) (Wu et al. 1999).
Reaction - small molecule participants:
H2O [cytosol]
CHOL3b,7a,25TRIOL [cytosol]
NADP+ [cytosol]
H+ [cytosol]
O2 [cytosol]
25OH-CHOL [cytosol]
NADPH [cytosol]
H2O [cytosol]
CHOL3b,7a,25TRIOL [cytosol]
NADP+ [cytosol]
H+ [cytosol]
O2 [cytosol]
25OH-CHOL [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-192065
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Reaction input - small molecules:
hydron
dioxygen
25-hydroxycholesterol
NADPH(4-)
hydron
dioxygen
25-hydroxycholesterol
NADPH(4-)
Reaction output - small molecules:
water
7alpha,25-dihydroxycholesterol
NADP(3-)
water
7alpha,25-dihydroxycholesterol
NADP(3-)
Reactome.org link: R-HSA-192065