Reaction: CYP17A1 17-hydroxylates P4 to 17aHPROG
- in pathway: Androgen biosynthesis
Progesterone (P4), NADPH + H+, and O2 react to form 17alpha-hydroxyprogesterone (17aHPROG), NADP+, and H2O. This reaction is catalyzed by steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), associated with the endoplasmic reticulum membrane.
Reaction - small molecule participants:
H2O [cytosol]
NADP+ [cytosol]
17aHPROG [cytosol]
P4 [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-193072
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Reaction input - small molecules:
progesterone
hydron
dioxygen
NADPH(4-)
Reaction output - small molecules:
water
NADP(3-)
17alpha-hydroxyprogesterone
Reactome.org link: R-HSA-193072