Reaction: CYP19A1 hydroxylates TEST to EST17b
- in pathway: Estrogen biosynthesis
The conversion of testosterone to estradiol is catalyzed by aromatase (CYP19A1) associated with the endoplasmic reticulum membrane.
Reaction - small molecule participants:
EST17b [cytosol]
H2O [cytosol]
NADP+ [cytosol]
HCOOH [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
TEST [cytosol]
Reactome.org reaction link: R-HSA-193143
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Reaction input - small molecules:
hydron
dioxygen
NADPH(4-)
testosterone
Reaction output - small molecules:
17beta-estradiol
water
NADP(3-)
formate
Reactome.org link: R-HSA-193143