Reaction: HSD11B2,HSD11B1 dimer oxidise CORT to COR
- in pathway: Glucocorticoid biosynthesis
Cortisol and NADP+ react to form cortisone, NADPH, and H+. This reaction is catalyzed by 11beta-hydroxysteroid dehydrogenases 11B1 and B2 (HSD11B1, B2), associated with the endoplasmic reticulum membrane. The conversion of cortisol (CORT), an active hormone, into inactive cortisone (COR) occurs in many tissues in the body, notably in the liver, and appears to play a role in regulating cortisol activity (Tannin et al. 1991, Stewart et al. 1987).
Reaction - small molecule participants:
H+ [cytosol]
NADPH [cytosol]
COR [cytosol]
CORT [cytosol]
NADP+ [cytosol]
Reactome.org reaction link: R-HSA-194023
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Reaction input - small molecules:
cortisol
NADP(3-)
Reaction output - small molecules:
hydron
NADPH(4-)
cortisone
Reactome.org link: R-HSA-194023