Reaction: DHF is reduced to tetrahydrofolate (THF)
- in pathway: Metabolism of folate and pterines
Cytosolic dihydrofolate reductase catalyzes the reaction of dihydrofolate, NADPH, and H+ to form tetrahydrofolate (THF) and NADP+ (Chen et al. 1984; Davies et al. 1990).
Reaction - small molecule participants:
THF [cytosol]
NADP+ [cytosol]
H+ [cytosol]
DHF [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-197972
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Reaction input - small molecules:
hydron
dihydrofolate(2-)
NADPH(4-)
Reaction output - small molecules:
(6S)-5,6,7,8-tetrahydrofolate(2-)
NADP(3-)
Reactome.org link: R-HSA-197972