Reaction: PLC-gamma1 hydrolyses PIP2
- in pathway: Generation of second messenger molecules
On recruitment to plasma membrane PLC-gamma1 then hydrolyses PIP2 producing two second messengers, diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). IP3 induces a transient increase in intracellular free Ca++, while DAG is a direct activator of protein kinase C (PKC theta). These process have been implicated in many cellular physiological functions like cell proliferation, cell growth and differentiation.
Reaction - small molecule participants:
I(1,4,5)P3 [cytosol]
DAGs [plasma membrane]
H2O [cytosol]
PI(4,5)P2 [plasma membrane]
I(1,4,5)P3 [cytosol]
DAGs [plasma membrane]
H2O [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-202407
======
Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
water
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1D-myo-inositol 1,4,5-trisphosphate(6-)
diglyceride
1D-myo-inositol 1,4,5-trisphosphate(6-)
diglyceride
Reactome.org link: R-HSA-202407