Reaction: CYP1B1 4-hydroxylates EST17b
- in pathway: Endogenous sterols
Cytochrome P450 1B1 (CYP1B1) can oxidise a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics as well as activating a range of procarcinogens. A specific substrate is the female sex hormone estradiol-17beta (EST17b) which is 4-hydroxylated to 4-hydroxyestradiol-17beta 4OH-EST17b) (Badawi et al. 2001).
Reaction - small molecule participants:
H2O [cytosol]
NADP+ [cytosol]
4OH-EST17b [cytosol]
EST17b [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-211951
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Reaction input - small molecules:
17beta-estradiol
hydron
dioxygen
NADPH(4-)
Reaction output - small molecules:
water
NADP(3-)
4-hydroxy-17beta-estradiol
Reactome.org link: R-HSA-211951