Reaction: PGE2 is converted to PGF2a by CBR1
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Carbonyl reductase (CBR1) aka prostaglandin 9-keto reductase inactivates prostaglandin E2 (PGE2) by converting it to prostaglandin F2alpha (PGF2a) (Wermuth 1981, Miura et al. 2008).
Reaction - small molecule participants:
NADP+ [cytosol]
PGF2a [cytosol]
H+ [cytosol]
NADPH [cytosol]
PGE2 [cytosol]
Reactome.org reaction link: R-HSA-2161651
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Reaction input - small molecules:
hydron
NADPH(4-)
prostaglandin E2
Reaction output - small molecules:
NADP(3-)
prostaglandin F2alpha
Reactome.org link: R-HSA-2161651