Reaction: MDMQ10H2 is methylated to DMQ10H2 by COQ5
- in pathway: Ubiquinol biosynthesis
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) catalyses the C-methyltransferase conversion of 2-methoxy-6-decaprenyl-1,4-benzoquinol (MDMQ10H2) to 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol (DMQ10H2). This reaction is inferred from the equivalent reaction in yeast (Barkovich et al. 1997).
Reaction - small molecule participants:
AdoHcy [mitochondrial matrix]
DMQ10H2 [mitochondrial matrix]
H+ [mitochondrial matrix]
MDMQ10H2 [mitochondrial matrix]
AdoMet [mitochondrial matrix]
Reactome.org reaction link: R-HSA-2162188
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Reaction input - small molecules:
2-decaprenyl-6-methoxyhydroquinone
S-adenosyl-L-methionine
Reaction output - small molecules:
S-adenosyl-L-homocysteine
2-decaprenyl-6-methoxy-3-methylhydroquinone
hydron
Reactome.org link: R-HSA-2162188