Reaction: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
- in pathway: NADPH regeneration
Cytosolic IDH1 (isocitrate dehydrogenase 1) homodimer catalyzes the reaction of isocitrate and NADP+ to form 2-oxoglutarate, CO2, and NADPH + H+. The same enzyme can also localize to peroxisomes (Geisbrecht and Gould 1999; Xu et al. 2004).
Reaction - small molecule participants:
2OG [cytosol]
H+ [cytosol]
CO2 [cytosol]
NADPH [cytosol]
ISCIT [cytosol]
NADP+ [cytosol]
Reactome.org reaction link: R-HSA-389540
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Reaction input - small molecules:
D-threo-isocitrate(3-)
NADP(3-)
Reaction output - small molecules:
2-oxoglutarate(2-)
hydron
carbon dioxide
NADPH(4-)
Reactome.org link: R-HSA-389540