Reaction: Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Phospholipase C beta-1 associated with the G(q) complex in the plasma membrane catalyzes the hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate to yield D-myo-Inositol 1,4,5-trisphosphate and 1,2-Diacylglycerol.
Reaction - small molecule participants:
I(1,4,5)P3 [cytosol]
DAG [plasma membrane]
H2O [cytosol]
PI(4,5)P2 [plasma membrane]
I(1,4,5)P3 [cytosol]
DAG [plasma membrane]
H2O [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-399998
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
water
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1D-myo-inositol 1,4,5-trisphosphate(6-)
1,2-diacyl-sn-glycerol
1D-myo-inositol 1,4,5-trisphosphate(6-)
1,2-diacyl-sn-glycerol
Reactome.org link: R-HSA-399998