Reaction: sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]
- in pathway: Sphingolipid metabolism
PPAP2A (phosphatidate phosphohydrolase type 2A) enzyme associated with the plasma membrane catalyzes the hydrolysis of extracellular sphingosine 1-phosphate to form sphingosine and orthophosphate (Roberts et al 1998).
Reaction - small molecule participants:
Pi [extracellular region]
SPG [extracellular region]
S1P [extracellular region]
H2O [extracellular region]
Reactome.org reaction link: R-HSA-428690
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Reaction input - small molecules:
sphingosine 1-phosphate(1-)
water
Reaction output - small molecules:
hydrogenphosphate
sphingoid base(1+)
Reactome.org link: R-HSA-428690