Reaction: sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]
- in pathway: Sphingolipid metabolism
PPAP2A, B, and C (phosphatidate phosphohydrolase type 2A, B, and C) enzymes associated with the plasma membrane catalyze the hydrolysis of cytosolic sphingosine 1-phosphate to form sphingosine and orthophosphate (Roberts et al 1998).
Reaction - small molecule participants:
SPG [cytosol]
Pi [cytosol]
S1P [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-428696
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Reaction input - small molecules:
sphingosine 1-phosphate(1-)
water
Reaction output - small molecules:
sphingoid base(1+)
hydrogenphosphate
Reactome.org link: R-HSA-428696