Reaction: HSD17B11 dehydrogenates EST17b to E1
- in pathway: Estrogen biosynthesis
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) may participate in androgen metabolism during steroidogenesis where it dehydrogenates estradiol-17-beta (EST17b) to estrone (E1) (Chai et al. 2003).
Reaction - small molecule participants:
H+ [cytosol]
E1 [cytosol]
NADPH [cytosol]
EST17b [cytosol]
NADP+ [cytosol]
Reactome.org reaction link: R-HSA-5693390
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Reaction input - small molecules:
17beta-estradiol
NADP(3-)
Reaction output - small molecules:
hydron
estrone
NADPH(4-)
Reactome.org link: R-HSA-5693390