Reaction: PIP2 hydrolysis
- in pathway: Role of second messengers in netrin-1 signaling
PIP2 hydrolysis appers to be an important mechanism for netrin-1 mediated neurite elongation. Netrin-1 alone could not elicit hydrolysis of PIP2 but depends on the stimulation of DCC and PLCgamma.
Reaction - small molecule participants:
I(1,4,5)P3 [cytosol]
DAGs [plasma membrane]
H2O [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-622382
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1D-myo-inositol 1,4,5-trisphosphate(6-)
diglyceride
Reactome.org link: R-HSA-622382