Reaction: TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)
- in pathway: Synthesis of wybutosine at G37 of tRNA(Phe)
As inferred from homologs in Saccharomyces cerevisiae, TRM12 transfers an aminocarboxypropyl group from S-adenosymethionine to yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe), yielding yW-86 (7-((3S)-3-amino-3-carboxypropyl)-4-demethylwyosine) and S-methyl-5'-thioadenosine.
Reaction - small molecule participants:
MTAD [cytoplasm]
AdoMet [cytoplasm]
Reactome.org reaction link: R-HSA-6782893
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Reaction input - small molecules:
S-adenosyl-L-methionine
Reaction output - small molecules:
5'-S-methyl-5'-thioadenosine
Reactome.org link: R-HSA-6782893