Reaction: KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine
- in pathway: tRNA modification in the nucleus and cytosol
KIAA1456 (TRM9L, hTRM9L) transfers a methyl group from S-adenosylmethionine (AdoMet) to 5-carboxymethyluridine in tRNA, yielding 5-methoxycarbonylmethyluridine (5-(2-methoxy-2-oxoethyl)uridine) (Begley et al. 2013). The subcellular location of the reaction is unknown.
Reaction - small molecule participants:
AdoHcy [cytoplasm]
AdoMet [cytoplasm]
Reactome.org reaction link: R-HSA-6786567
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Reaction input - small molecules:
S-adenosyl-L-methionine
Reaction output - small molecules:
S-adenosyl-L-homocysteine
Reactome.org link: R-HSA-6786567