Reaction: NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841
- in pathway: rRNA modification in the mitochondrion
MTERF4 forms a complex with NSUN4 (Camara et al. 2011, Spahr et al. 2012, Yakubovskaya et al. 2012) and recruits NSUN4 to the ribosome where NSUN4 transfers a methyl group from S-adenosylmethionine to the 5 position of cytidine-841 in 12S rRNA (Camara et al. 2011). Knockout of MTERF4 in mice is lethal and cardiomyocyte-specific knockout is accompanied by mitochondrial cardiomyopathy (Camara et al. 2011).
Reaction - small molecule participants:
AdoHcy [mitochondrial matrix]
AdoMet [mitochondrial matrix]
Reactome.org reaction link: R-HSA-6793057
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Reaction input - small molecules:
S-adenosyl-L-methionine
Reaction output - small molecules:
S-adenosyl-L-homocysteine
Reactome.org link: R-HSA-6793057