Reaction: glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
- in pathway: TP53 Regulates Metabolic Genes
Cytosolic glutathione reductase catalyzes the reaction of glutathione (oxidized) and NADPH + H+ to form two molecules of glutathione (reduced) and NADP+ (Scott et al. 1963, Loos et al. 1976). Deficiency of glutathione reductase can cause hemolytic anemia.
Reaction - small molecule participants:
GSH [cytosol]
NADP+ [cytosol]
H+ [cytosol]
NADPH [cytosol]
GSSG [cytosol]
GSH [cytosol]
NADP+ [cytosol]
H+ [cytosol]
NADPH [cytosol]
GSSG [cytosol]
GSH [cytosol]
NADP+ [cytosol]
H+ [cytosol]
NADPH [cytosol]
GSSG [cytosol]
Reactome.org reaction link: R-HSA-71682
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Reaction input - small molecules:
hydron
NADPH(4-)
glutathione disulfide(2-)
hydron
NADPH(4-)
glutathione disulfide(2-)
hydron
NADPH(4-)
glutathione disulfide(2-)
Reaction output - small molecules:
glutathionate(1-)
NADP(3-)
glutathionate(1-)
NADP(3-)
glutathionate(1-)
NADP(3-)
Reactome.org link: R-HSA-71682