Reaction: AICAR + 10-Formyl-THF => FAICAR + THF
- in pathway: Purine ribonucleoside monophosphate biosynthesis
The irreversible transfer of a formyl group to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR), to yield 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR), is catalyzed by the phosphoribosylaminoimidazolecarboxamide formyltransferase activity of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enzyme. This cytosolic protein occurs primarily as a dimer (Rayl et al. 1996; Vergis et al. 2001) and may further associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).
Reaction - small molecule participants:
THF [cytosol]
FAICAR [cytosol]
10-formyl-THF [cytosol]
AICAR [cytosol]
Reactome.org reaction link: R-HSA-73798
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Reaction input - small molecules:
10-formyltetrahydrofolate(2-)
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
Reaction output - small molecules:
(6S)-5,6,7,8-tetrahydrofolate(2-)
5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
Reactome.org link: R-HSA-73798