Reaction: acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O
- in pathway: Fatty acyl-CoA biosynthesis
Cytosolic fatty acid synthase (FAS) complex catalyzes the reaction of acetyl-CoA with 7 malonyl-CoA and 14 NADHP + 14 H+ to form a molecule of palmitate and 7 CO2, 14 NADP+, 8 CoASH, and 6 H2O. The process proceeds via the successive condensations of malonyl groups onto the growing acyl chain,each followed by loss of CO2 and three steps of reduction (Smith et al. 2003).
Reaction - small molecule participants:
H2O [cytosol]
CO2 [cytosol]
NADP+ [cytosol]
PALM [cytosol]
CoA-SH [cytosol]
H+ [cytosol]
Ac-CoA [cytosol]
NADPH [cytosol]
Mal-CoA [cytosol]
Reactome.org reaction link: R-HSA-75872
======
Reaction input - small molecules:
hydron
acetyl-CoA(4-)
NADPH(4-)
malonyl-CoA(5-)
Reaction output - small molecules:
water
carbon dioxide
NADP(3-)
hexadecanoic acid
coenzyme A(4-)
Reactome.org link: R-HSA-75872