Reaction: HSD17B1 hydrogenates E1 to EST17b
- in pathway: Estrogen biosynthesis
Expression of HSD17B1 which is the main enzyme that catalyzes the hydrogenation of estrone is strongly restricted to placenta, ovaries, endometrium and breast tissue (Moeller and Adamski, 2009).
Reaction - small molecule participants:
EST17b [cytosol]
NADP+ [cytosol]
H+ [cytosol]
E1 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-804969
======
Reaction input - small molecules:
hydron
estrone
NADPH(4-)
Reaction output - small molecules:
17beta-estradiol
NADP(3-)
Reactome.org link: R-HSA-804969