Reaction: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
- in pathway: Erythropoietin activates Phospholipase C gamma (PLCG)
Phospholipase C gamma (PLCG1 or PLCG2) bound to the phosphorylated cytoplasmic domain of the EPO receptor (EPOR) hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to yield the second messengers diacylglycerol and 1D-myo-inositol 1,4,5-trisphosphate (Ren et al. 1994, and inferred from mouse). Erythropoietin may also activate the hydrolysis of phosphatidylcholine and phosphatidylethanolamine (inferred from mouse homologs),
Reaction - small molecule participants:
I(1,4,5)P3 [cytosol]
DAGs [plasma membrane]
H2O [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-9032478
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1D-myo-inositol 1,4,5-trisphosphate(6-)
diglyceride
Reactome.org link: R-HSA-9032478