Reaction: PRMT1 methylates ESRs
- in pathway: Extra-nuclear estrogen signaling
ESR1 is methylated by PRMT1 at arginine 260 in response to E2 stimulation. Methylation is required for rapid non-genomic signaling by E2 and promotes the interaction of ESR1 with the p85 regulatory subunit of PI3K, SRC and PTK2 (FAK) (Simoncini et al, 2000; Le Romancer, 2008; reviewed in Arnal, 2017). Although this reaction is shown preceding palmitoylation of ESR1, the sequence of these two events is not established.
Reaction - small molecule participants:
AdoHcy [cytosol]
AdoMet [cytoplasm]
Reactome.org reaction link: R-HSA-9632182
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Reaction input - small molecules:
S-adenosyl-L-methionine
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-9632182