Reaction: SPHK2 phosphorylates SPG to S1P
- in pathway: Sphingolipid de novo biosynthesis
The cytosolic enzyme sphingosine kinase 2 (SPHK2) catalyzes the phosphorylation of sphingosine (SPG) to sphingosine 1-phosphate (S1P) (Liu et al. 2000). In contrast to pro-survival SPHK1, the BH3-only protein SPHK2 inhibits cell growth and enhances apoptosis (Maceyka et al. 2005).
Reaction - small molecule participants:
S1P [cytosol]
ADP [cytosol]
ATP [cytosol]
SPG [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-9695949
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Reaction input - small molecules:
ATP(4-)
sphingoid base(1+)
Reaction output - small molecules:
sphingosine 1-phosphate(1-)
ADP(3-)
Reactome.org link: R-HSA-9695949