Reaction: Nucleoprotein is methylated by PRMT1
- in pathway: Maturation of nucleoprotein
Protein arginine methyltransferase 1 (PRMT1) methylates SARS-CoV-2 nucleoprotein on two arginines (R95 and R177). This modification is required for its RNA binding capacity, since treatment with a type I PRMT inhibitor (MS023) or substitution of R95K or R177K inhibited interaction with the 5’-UTR of the SARS-CoV-2 genomic RNA. Pre-treatment of VeroE6 cells with MS023 significantly reduced SARS-CoV-2 replication (Cai et al, 2021).
Reaction - small molecule participants:
H+ [cytosol]
S-adenosyl-L-homocysteine [cytosol]
S-adenosyl-L-methionine [cytosol]
Reactome.org reaction link: R-HSA-9729283
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Reaction input - small molecules:
S-adenosyl-L-methionine
Reaction output - small molecules:
hydron
S-adenosyl-L-homocysteine
Reactome.org link: R-HSA-9729283