Reaction: DHCR24 reduces LAN to 24,25-dhLAN

- in pathway: Cholesterol biosynthesis
DHCR24 (delta(24)-sterol reductase) (review Zerenturk et al. 2013) associated with the endoplasmic reticulum membrane catalyzes the reduction of lanosterol (LAN) to 24,25-dihydrolanosterol (24,25-dhLAN) (Kandutsch & Russell 1960). Like most cholesterol synthesis enzymes, DHCR24 is transcriptionally regulated by the SREBP family of transcription factors and hence, is subject to negative regulation by cholesterol (Zerenturk et al. 2012).
Reaction - small molecule participants:
NADP+ [cytosol]
24,25-dhLAN [endoplasmic reticulum membrane]
H+ [cytosol]
LAN [endoplasmic reticulum membrane]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-9755937

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Reaction input - small molecules:
hydron
ChEBI:15378
lanosterol
ChEBI:16521
NADPH(4-)
ChEBI:57783
Reaction output - small molecules:
NADP(3-)
ChEBI:58349
24,25-dihydrolanosterol
ChEBI:28113
Reactome.org link: R-HSA-9755937