Reaction: CYP21A2 21-hydroxylates PROG
- in pathway: Mineralocorticoid biosynthesis
Progesterone, NAPDH + H+, and O2 react to form 11-deoxycorticosterone, NADP+ and H2O. This reaction is catalyzed by CYP21A2 associated with the endoplasmic reticulum membrane.
Reaction - small molecule participants:
H2O [cytosol]
11DCORST [cytosol]
NADP+ [cytosol]
P4 [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
H2O [cytosol]
11DCORST [cytosol]
NADP+ [cytosol]
P4 [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-193964
======
Reaction input - small molecules:
progesterone
hydron
dioxygen
NADPH(4-)
progesterone
hydron
dioxygen
NADPH(4-)
Reaction output - small molecules:
water
11-deoxycorticosterone
NADP(3-)
water
11-deoxycorticosterone
NADP(3-)
Reactome.org link: R-HSA-193964